The Dow Jones Industrial Average opened down 0.3%, the S&P 500 dropped 0.4%, and the Nasdaq fell 0.6%.

Grail fell by 50.9% after one of its drugs failed in clinical trials. Cloud computing company Akamai dropped by 8.3% due to Q1 performance guidance falling below expectations. Industrial and specialty chemicals company Chemours decreased by 6.9% as its Q4 earnings per share were lower than expected. Online auto auction company Copart declined by 10.2% as its Q4 performance fell short of expectations. Residential real estate trading platform Opendoor rose by 16.4%, with Q4 revenue far exceeding expectations.